{"id":337,"date":"2026-02-09T11:52:35","date_gmt":"2026-02-09T11:52:35","guid":{"rendered":"https:\/\/researchchemicalshop.eu\/?post_type=product&p=337"},"modified":"2026-03-06T04:03:38","modified_gmt":"2026-03-06T04:03:38","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/researchchemicalshop.eu\/sk\/produkt\/escaline-hydrochloride\/","title":{"rendered":"Escaline hydrochloride"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c Chemische Specificaties<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyfenethylamine) hydrochloride is een semi-synthetisch phenethylaminederivaat dat structureel verwant is aan mescaline. Deze onderzoeksstof wordt bestudeerd vanwege zijn interessante farmacologische profiel.<\/p>\n

Kernparameters:<\/em><\/p>\n

    \n
  • \n

    IUPAC-naam<\/strong>: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride<\/p>\n<\/li>\n

  • \n

    Molecuulformule<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnos\u0165<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cistota<\/strong>: \u226598% (HPLC-UV bij 280 nm)<\/p>\n<\/li>\n

  • \n

    Formul\u00e1r<\/strong>: Wit kristallijn poeder<\/p>\n<\/li>\n

  • \n

    Smeltpunt<\/strong>: 243-245\u00b0C (ontleedt)<\/p>\n<\/li>\n

  • \n

    Oplosbaarheid<\/strong>: 50 mg\/ml in water, 30 mg\/ml in methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Wetenschappelijke Toepassingen<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmacologisch onderzoek<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A receptor binding studies (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Vergelijkende studies met mescaline en andere phenethylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Gedragsonderzoek<\/strong>:<\/p>\n

          \n
        • \n

          Effecten op diergedrag in gecontroleerde settings<\/p>\n<\/li>\n

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          Dosis-responsrelaties bij zoogdier-modellen<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolische studies<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkylatie kinetiek onderzoek<\/p>\n<\/li>\n

          • \n

            CYP2D6 interactieprofiel<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Aanbevolen Doseringen voor Onderzoek<\/strong><\/h4>\n

            Experimentele richtlijnen:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nD\u00e1vkovanie<\/th>\nAdministrat\u00edvna cesta<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nM\u00e9dium na kultiv\u00e1ciu buniek<\/td>\n<\/tr>\n
            Kleine dieren<\/td>\n1-5 mg\/kg<\/td>\nIntraperitone\u00e1lne<\/td>\n<\/tr>\n
            Primaten<\/td>\n0,2-1 mg\/kg<\/td>\n\u00dastne<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Let op: Dosisafhankelijke effecten boven 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Veiligheidsaspecten & Risico’s<\/strong><\/h4>\n
              \n
            1. \n

              Toxicologische data<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (muis, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/dag (28-daagse studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Profil ved\u013eaj\u0161\u00edch \u00fa\u010dinkov<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimale fysiologische effecten<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Sensorische modulatie<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenti\u00eble hemodynamische effecten<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritische interacties<\/strong>:<\/p>\n

                    \n
                  • \n

                    Gevaarlijk<\/strong>: MAO-remmers, serotonergische middelen<\/p>\n<\/li>\n

                  • \n

                    Risicovol<\/strong>: Vasoconstrictoren, antipsychotica<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kontrola kvality a analytick\u00e9 \u00fadaje<\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistota HPLC<\/strong>: 98,2% (C18-kolom, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Zvy\u0161kov\u00e9 rozp\u00fa\u0161\u0165adl\u00e1<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      \u00dadaje o stabilite<\/strong>:<\/p>\n

                        \n
                      • \n

                        Houdbaarheid: 24 maanden bij -20\u00b0C<\/p>\n<\/li>\n

                      • \n

                        Pokojov\u00e1 teplota: 6 mesiacov (pod arg\u00f3nom)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Veelgestelde Onderzoeksvragen<\/strong><\/h4>\n

                        Q1: Wat is het werkingsmechanisme?<\/strong>
                        \nA: Primaire werking als 5-HT\u2082A receptoragonist met secundaire effecten op dopaminerge systemen.<\/p>\n

                        Q2: Hoe verhoudt de potentie zich tot mescaline?<\/strong>
                        \nA: Ongeveer 1,5x hogere receptoraffiniteit maar langere werkingsduur (8-10 uur).<\/p>\n

                        Q3: Wat zijn optimale opslagcondities?<\/strong>
                        \nA: In amberkleurige vials onder inert gas bij -20\u00b0C.<\/p>\n

                        Q4: Zijn er genotoxische risico’s?<\/strong>
                        \nA: Ames-test negatief bij <1 mM, maar beperkte chromosoomtestdata.<\/p>\n

                        \ud83d\udccc Onderzoeksbeperkingen<\/strong><\/h4>\n
                          \n
                        • \n

                          Beperkte data over chronische blootstelling<\/p>\n<\/li>\n

                        • \n

                          Onbekende effecten op neuroplasticiteit<\/p>\n<\/li>\n

                        • \n

                          Variabele interspecies metabolisme<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusie voor Wetenschappers<\/strong><\/h4>\n

                          Escaline hydrochloride biedt waardevolle mogelijkheden voor vergelijkend serotoninerg onderzoek, met een unieke combinatie van stabiliteit en werkingsduur. De hydrochloridevorm garandeert uitstekende oplosbaarheid voor laboratoriumtoepassingen.<\/p>\n

                          Belangrijke disclaimer: Dit product is uitsluitend bestemd voor wetenschappelijk onderzoek in geaccrediteerde laboratoria. Niet voor humaan gebruik of diagnostische toepassingen. Alle experimenten moeten worden uitgevoerd in overeenstemming met lokale regelgeving en ethische richtlijnen.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochloride eigenschappen<\/span><\/h3>\n

                          Synoniem:<\/strong> 3,5-dimethoxy-4-ethoxyphenethylamine hydrochloride
                          \nCAS Nummer:<\/strong> 39201-82-6
                          \nFormule:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyphenyl}ethan-1-amine hydrochloride
                          \nMolmassa:<\/strong> 261.8 g\/mol
                          \n\u010cistota:<\/strong> >97%<\/p>","protected":false},"featured_media":16981,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[17,183,18],"product_tag":[186,187,1003,22],"class_list":{"0":"post-337","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-escalin","10":"product_tag-escalin-kopen","11":"product_tag-escaline-hydrochloride","12":"product_tag-nl","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product\/337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/comments?post=337"}],"version-history":[{"count":1,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product\/337\/revisions"}],"predecessor-version":[{"id":16725,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product\/337\/revisions\/16725"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/media\/16981"}],"wp:attachment":[{"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/media?parent=337"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=337"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=337"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalshop.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}